Have voice sets
Those should be are immortal (most placed NPCs should be immortal, unless there is specific reasons not to), i.e. set Immortal flag, do not set plot, and no perm death flag.
have atleast some conversation (a generic greeting if nothing else) (more)
Most have deity set (unless there is specific reasons why they do not belive in gods. Most people in derimir belive in storm, most people in ferder belive in dragonlord etc).
Have unique tags and resrefs (unique tags also for guards and so).
Are not disarmable unless intended
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have a description
if they are important NPCs which DMs can use include book to the NPCs inventory containing the history about the character, and also other relevant information to the DMs.
All NPCs should be put to the race specific palette. There is no need to put named placed NPCs to palette (i.e. guild master Jack, or Guild Shopkeeper, or senior master Bizriaco etc), DMs can get them from the guild area. All generic (unnamed) NPCs should be in the palette (i.e. guild guard, generic guild member etc), so DMs can fetch them and use them on quests.
If placed on palette make sure that the First name is the one that identifies the NPCs, as it is the only thing shown to the DMs/Toolset.